Tim Berners Lee: The Inventor Of The Internet

Tim Berners leeward The Inventor Of The meshworkMany passel hold up had a important impact on the ground of population media that radically changed how the world glide bys in coiffureion. unmatchable(a) warning of whatever unitary and only(a) who has done just that would be Tim Berners-Lee, who is best cognise for his innovation The innovation all-encompassing Web. Tim Berners-Lee has impacted the world of mass media in several ways. First, Tim Berners-Lee invented the World Wide Web. Second, since the World Wide Web was invented, it has radically changed the way that the people communicate. Third, the net profit has revolutionized how the press forces schooling to the people. Finally, while the lucre has its advantages, it has had alot to a greater extent than its treat of controversy.First, Tim Berners-Lee invented the World Wide Web. The story behind the aim of the internet is an interesting one. It all began around 1980 while Tim Berners-Lee was working as a software engineer at the European Laboratory for division Physics in Geneva, Switzerland besides known as CERN. He cute to figure out a new way to harmoniumize his notes in a brain-like way, but while improving upon the abilities of that occasionally memory-constrained organ and came up with a new way of doing it building a software schedule called Enquire (TIME). Using the ideas that he theatrical roled to build Enquire and former(a)(a) ideas that were up-to-date at the sentence, he take a leakd another way of finding files on his calculating machine by creating a grammatical case of hypertext notebook that allows the text in a document to be linked to other files on the computer. He so thought about accessing materials on other computers. He then thought about opening his computer to not unaccompanied his coworkers at CERN, but to the scientific companionship every(prenominal)where. By using this quality of ne iirking purpose by connecting individual computers together on a network, it would mean no primordialized dodging. This would mean that the new network would go for no shake up with scalability, which means that it could grow to infinity. Tim Berners-Lee then built a coding system that was easy to learn and spend to build sack up pages. It is called HyperText Mark-up Language, also nearly known as hypertext markup language. It has become the most wildly utilise expression that web developers or even normal people implement to manufacture web pages and sites. He then created e new set of protocols that allowed these HTML documents to be connected across the profits called HyperText Transfer Protocol, also come up known as HTTP. Soon after that, Tim Berners-Lee wrote the code for the freshman web browser, which allowed droprs around the world to access web pages on the internet. Once the World Wide Web debuted in 1991, the world of mass media changed forever as it brought smart set and clarity to the chaos that was cy berspace. The World Wide Web (the information-sharing warning built for the internet that is the way accessing and sharing information on the internet) and mesh (the massive network of computers) consumed growth at exponential order (The Difference). At one point, the number of internet users was doubling every 53 days (TIME). Clearly, Tim Berners-Lees inventions made a huge impact on the mass media industry.Second, since the World Wide Web was invented, it has radically changed the way that the people communicate. Since the Internet was first brought online, galore(postnominal) social networking sites induce radically changed how people, businesses and organizations communicate. One of those websites is Facebook. With Facebook, anyone could create a profile on the site and not tho chain mail their thoughts on their wall for friends to see and comment on, but also use instant messaging to talk to friends in sure-time and even destiny photos and pictorial matters mingled with friends or even everyone on Facebook. Facebook has evolved the way that people communicate in several ways. One example is how easy it is for anyone to click the attention deficit disorder Friend and reconnect with old friends. some other example is how the sheer number of people using Facebook affects the mass media, numbering in the hundreds of millions, possibly soon to be in the billions. Because of how many people use Facebook, the chances are good that anyone wanting(p) to find old friends would find them on Facebook. Businesses who want to advertize would use Facebook because their ads would reach a very large amount of people. Organizations who create community pages or radicals for a specific cause could also speak to a very large amount of people. some other great example is how Facebook is real time and very easy to update. Since Facebook is real time, people could keep their profiles current from anywhere with just second bases of work at a time, even from res tless(prenominal) devices such(prenominal) as cell phones. This also allows people to share events as they happen deep down seconds (Welcome)(NEWS). Clearly, Tim Berners-Lees invention allowed the social networking sites to form and they evolved the way that people communicate. The globular nature of the Internet and the World Wide Web only helps to let sites like this expand on a huge scale.Third, the internet has revolutionized how the press gets information to the people. For hundreds of years, the newspaper has been the best known and well used source of information on current events. However, in recent years, its popularity has declined. Nowadays, 61% of citizens in the western world get their news from the Internet, pard to 17% who get their news from the newspaper. This could be for several reasons. One reason would be that people could access up-to-minute news on the internet at any time from any location if they want to because of the nature of the internet and the evolu tion of mobile devices that have the capability to access it. There is no need to go to a newsstand or store to buy a newspaper to occupy news that might be out of date. Another reason is that publication a story on the internet is also much easier and less expensive than publishing it on printed media. Internet news could also have photos and video supporting the text on a new agencys website. Another reason would also be that the news is available to many more people due to the worldwide nature of the internet (What are)(Newspapers). Another mainstream format that the internet is quickly replacing would be television. Internet television and drift video are supplying news in about the same format as television with full motion video. Internet video is also easier to set up and less expensive to put a video online or watch it (Internet). Clearly, Tim Berners-Lees inventions revolutionized how the press gets information to the people.Finally, while the Internet has its advantage s, it has had alot more than its share of controversy. Since Tim Berners-Lee invented the internet, it has caused many controversies in the world. One key example of a signifi evictt bug out in many countries that the internet has provided is the use of censorship to filter obscene materials and the worldwide nature of the network. Some countries, such as China have responded with a strict internet censorship scheme that regulates what types of content the people may read or write. In fact, the censorship scheme has been apt(p) the nickname The Great Firewall of China in popular culture because it blocks thousands of websites that the Chinese government feels are a panic to the country and society. It also affects the ability of the press to report current events freely and without restriction. This was especially a huge issue during the Beijing Olympics, where at that place were many foreign journalists on site. Another key issue that the internet has caused is the issue of pri vacy. One major breach of privacy that involves the internet would be Google road View. Google Street View is part of Google Maps and it allows anyone to view an area as if they were stand up on a street. Google uses specially modified vehicles with cameras that take pictures in every direction as the car drives along. These pictures are then uploaded to Google Maps and allow users to use them in addition to maps to look at an area. This has caused major privacy problems because on that point are several occasions when the vehicle takes photos of people on close property that do not wish to be photographed for various reasons. eyepatch Google does offer users the option of reporting individual images to request their removal from the web, that that would be after the fact and the image could have be saved by anyone prior to removal (15 Biggest). Clearly, Tim Berners-Lee has made a significant impact on the world of mass media because while his inventions created many advantages to how media is delivered to the people, it also creates massive controversies in the process.Tim Berners-Lee has had a significant impact on the world of mass media that radically changed how the world communicates information. His innovations that caused these changes are the World Wide Web and the Internet. Tim Berners-Lee has impacted the world of mass media in several ways. First, Tim Berners-Lee invented the World Wide Web. Second, since the World Wide Web was invented, it has radically changed the way that the people communicate. Third, the internet has revolutionized how the press gets information to the people. Finally, while the World Wide Web and the Internet has its advantages, it has had alot more than its share of controversy. Clearly, Tim Berners-Lee has impacted the world of mass media in many ways, positive and negative.Gauchers Disease Types, Symptoms and TreatmentsGauchers Disease Types, Symptoms and TreatmentsNew Treatment Plans Give confide to Patients with Ga uchers DiseaseKatherine VanGauchers disorder occurs within individuals because they lose the enzyme glucocerebrosidase in the body, which is responsible for breaking down copiousty substances called glucocerebroside. Consequently, large amounts of productive substances are able to build up and stay in the liver, spleen, lungs, jampack marrow and brain because of the damaged and lack of glucocerebrosidase. Hence, the disorder is also called glucocerebrosidase deficiency. either age conference can be diagnosed with this disease, but studies scan that there is a higher percentage of the disease in Eastern and fundamental European Jewish people. There are many types of Gauchers disease. The first form is called non-neuronopathic Gauchers disease because it does not target and damage the central nervous system. The symptoms areThinning of bonesExtreme bone disoblige and bone fracturesEnlarged liverEnlarged spleen execrable amounts of sun-loving red blood cellsExcessive fatig ueVulnerability to bruisingLow amounts of blood blood plateletsYellow spots in the eyesRegular nosebleedsThe second type of Gauchers disease is neuronopathic and it can be life-threatening because it reparation the central nervous system. Babies after three months of birth can be diagnosed with this form of Gauchers disease. Its symptoms are similar to the non-neuronopathic form, but it also includes wizard problems, including dementiaSevere inflexibilitySeizuresThe last form of Gauchers disease is called perinatal lethal and it is the most severe type. In fact, most infants with perinatal lethal die after a few days of birth. The symptoms listed at a lower placeExtensive swelling due to changeful accumulationDry and leprose skinSerious neurological problemsGauchers disease develops as a result of athleticss in the GBA gene. The GBA gene is responsible for making glucocerebrosidase enzymes, which simplifies glucocerebroside molecules into sugars and smaller fat molecules. How ever, mutations in the GBA gene impact the ability of the enzymes to function properly. Consequently, the large amounts of fatty substances cause organ failure. Patients can be diagnosed with Gauchers disease because of an hereditary pattern pattern called autosomal recessive. The parents must be carriers of a Gauchers genetic mutation in order for the children to have Gauchers disease. Nevertheless, there is only a 25 percent chance that their child will be diagnosed with the disease.In order to let out and track the progression of Gauchers disease within uncomplainings, a series of diagnosis and running games are used. Enzyme analysis uses blood screen outs to identify a patients levels of glucocerebrosidase. If Gauchers disease was active in the patient, there are low levels of glucocerebrosidase in the blood. On the other hand, carriers have enzyme levels between the affected and unaffected people who are not carriers. Another test is called the genetic mutation analysis an d it tries to find mutations in the genes harmonize with Gauchers disease. However, not all of the genetic mutations involved in Gauchers disease have been identified thus this test is used to help classify which type of Gauchers disease patients have. In order to measure the progression of the disease, dual postcode X-ray absorptiometry (DXA), and magnetized resonance imaging (MRI) can also be used. DXA uses low energy X-rays to measure bone density, while MRI uses charismatic fields and radio waves to create images of organs. MRI can show organ enlargement, such as the spleen or liver. In addition, doctors perform prenatal testing in pregnant women that are carriers of Gauchers disease to test if Gauchers disease is active in the fetus. Doctors will analyze the amniotic fluid or tissues from the placenta to complete the prenatal testing.Gauchers disease cannot be cured it is only controlled or make outd. The type of interference given to patients varies depending on the type and stiffness of Gauchers disease and condition of patients. One manipulation given is the enzyme backup man therapy, where fill-in enzymes in liquid substances are injected into the veins of patients every two-weeks. This type of treatment is effective within individuals with non-neuronopathic Gauchers disease. Nevertheless, people may regularly experience an allergic reaction to the enzyme treatment. Another treatment method available is the bone-marrow transplantation. This is a surgical procedure that is used for severe cases of Gauchers disease, where damaged blood-forming cells are removed(p) and replaced. However, this medical treatment is not as common as the enzyme replacement therapy because it has more threats and hazards. Lastly, medication can also be used to manage Gauchers disease. The oral medication miglustat (Zavesca) is an effective drug that minimizes the build-up of the fatty substances in non-neuronopathic Gauchers disease. Nevertheless, the medication ca n cause side set up in the digestive system, such as diarrhea and, weight loss. Furthermore, the drug can also interfere with sperm production. In ladies, birth control is well-advised while using miglustat and for three months after they stop using the drug.In December 2001, Genzyme, a Sanofi Company completed a study to compare the effectiveness of a drug, Cerezyme, in two different sexually transmitted disease amounts in their patients with Gauchers disease. Both males and females ages 18 and older were eligible for study. Nevertheless, only patients with type 1, non-neuronopathic Gauchers disease were allowed to participate. There were multiple research centers that participated in the lab, including 18 in the United States, one in Canada, six in Europe, and one in Brazil. During the study, 90 participants were haphazardized and placed into two groups. The first group of people authentic their monthly dose of Cerezyme in two infusions one infusion per two weeks (Q2). The s econd group of individuals received their monthly dosage in one infusion every month (Q4). The progression of the effects of the drug on the Gauchers disease was monitored by measuring the haemoglobin determine and platelet count of patients. Magnetic resonance imaging and computer tomography were also used to explore any improvements in the patients liver and spleen conditions. Moreover, researchers tried to identify if the change in dosage reduced the symptoms of patients, such as fatigue, vulnerability to bruising and chickenhearted spots in the eyes.Genzyme believed that patients who received one infusion every 2 weeks would show a more positive reaction towards their non-neuronopathic Gauchers disease because there was a longer period of time in between the monthly dosage sessions of Q4. Hence, this could cause a deficiency of all the replaced glucocerebrosidase at the end of the month. Conversely, Q2 would be more stabilized because the enzyme glucocerebroside would be repl aced every two weeks. In theory, by the end of each month, only half of the enzyme glucocerebroside would be deficient. Similarly, the findings of the lab, displayed in table one, showed that 80.8% of the participants of Q2 Cerezyme showed clinical achievement, whereas there was only 63.2% of clinical success within individuals using Q4 Cerezyme. Hence, Q2 was a better drug frequency in terms of safety and efficacy.Q2 CerezymeQ4 Cerezyme total of Participants Analyzed2657 human activity of participants with Clinical mastery2136Proportion of participants with Clinical Success80.8%63.2%Table 1 Number of Participants with Clinical Success after the shutting of the Clinical TrialThe map above portrays the number of participants that showed improvements in their Gauchers disease in comparison to their condition before the clinical trial. For example, some participants noticed a reduction of symptoms, such as extreme tiredness, bruising, scandalmongering spots in the eyes, and nosebl eeds. As well, there were some improvements in haemoglobin values, platelet count, and liver and spleen conditions.A similar lab was conducted to test the efficacy of two dosage amounts in an enzyme replacement therapy on February 1, 2007. The global specialty biopharmaceutical company, Shire, wanted to test VPRIV, a hydrolytic lysosomal glucocerebrosidase-specific enzyme, that was used in long-run enzyme replacement therapy for patients with type 1 Gauchers disease. The controlled variable of the study were the 45 and 60 U/kg dosages of VPRIV, also known as velaglucerase alfa (GA-GCB), given to patients with type one Gauchers disease. Shire also used random trials to divide the participants into two groups that received the dosage every other week. Nevertheless, one group received 45 U/kg and the other group received 60 U/kg of VPRIV. Ages two and older of two genders were allowed to participate in the study. The duration of treatment for each patient was 12 months, where the fi rst patient enrolled into the study on January 11, 2007, and the last patient participated in the research project on April 8, 2008. The progression of the effects of the drug on Gauchers disease was monitored by measuring the hemoglobin values and platelet count of patients. Magnetic resonance imaging and computer tomography were also used to explore any improvements of the patients liver and spleen conditions.Shire believed that 60 U/kg of VPRIV was a better treatment towards the non-neuronopathic Gauchers disease, assuming that VPRIV was safe and efficient, because there were more artificial enzymes. The data collected in table two supported their hypothesis as the intermediate change of baseline of Gauchers disease was better in the twelve participants that used 60 U/kg of VPRIV every other week. A baseline is the initial amount of a substance where the last amount is compared to. A baseline is also referred to as the reference point. The chart supports Shires hypothesis as the spleen and liver volumes of VPRIV 45 U/kg patients decreased and hemoglobin and platelet concentrations increased towards a more normalized size or amount. Nevertheless, the research is still continuing and the data released is not fully up to date.VPRIV 45 U/kg, Every different WeekVPRIV 60 U/kg, Every Other WeekNumber of Participants Analyzed1312Average Change of Baseline of spleen Volume (units Percent body weight)-1.87-1.92Average Change of Baseline of coloured Volume (units Percent body weight)-0.30-0.84Average Change of Baseline of hemoglobin Concentration (units g/dL)2.4292.438Average Change of Baseline of Platelet Counts (units x109/L)40.9250.88Table 2 Change of Baseline of Gauchers Disease in Participants After 12 Month TreatmentThe chart above portrays the average change of baseline of spleen volume, liver volume, hemoglobin concentration and platelet counts for two groups of patients those who received 45 U/kg of VPRIV, and other who received 60 U/kg of VPRIV every other week. Negative values bear witness a decrease in size, whereas positive values indicate an increase in size. The data was collected by using magnetic resonance imaging and analyzing participates blood tests.Overall, studies cut across to occur in order to find more effective treatments for individuals suffering from Gauchers disease. The severity of this disease may vary from patients, but in general, the disease is very destructive as it can lead to deaths in young age groups. Gauchers disease attacks important organs in the body, such as the liver, spinal anesthesia cord, heart and brain, and prevents the organs from functioning properly. Nevertheless, the disease only occurs due to genetic science and the positive research projects conducted on Gauchers disease will continue to bring hope in humans.Referenceshttp//www.convertunits.com/info/dlhttp//www.nlm.nih.gov/medlineplus/ency/article/003647.htmhttp//www.cancer.ca/en/cancer-information/cancer-type/childhood-cancer-in formation/supportive-care/symptom-and-side-effect-management/low-platelet-count/?region=nuhttp//www.lilly.com/products/patient-safety/providers-role/Pages/adverse-event.aspxhttp//www.drugs.com/monograph/cerezyme.htmlhttp//www.mayoclinic.org/diseases-conditions/gauchers-disease/basics/coping-support/con-20031396http//ghr.nlm.nih.gov/condition/gaucher-diseasehttp//www.shirecanada.com/en/default.aspxhttp//www.vpriv.com/about-vpriv/http//clinicaltrials.gov/ct2/show/results/NCT00430625?term=gaucher+diseaserank=13sect=X012http//clinicaltrials.gov/ct2/show/NCT00364858?term=Gaucher%27s+Diseaserank=3